Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.6
USERS' SCORE
Good
Based on 18 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
9
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Read More
9
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
Read More
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
Most Useful Reviews
9
Increased ferritin levels
34 people found this helpful
I had latent iron deficiency anaemia and tried various pharmaceutical iron supplements, but my ferritin level remained low. In desperation, I ordered Iron from Garden of Life, and after three months, my ferritin rose to normal levels. This product works excellently and is gentle on the stomach. I'm feeling stronger, my hair has stopped falling out, and my general well-being has improved. I highly recommend this complex!
Read More
9
Enhanced energy
12 people found this helpful
Great iron! I bought this after positive reviews, and it really uplifted my spirits throughout the day. I've managed demanding tasks without feeling exhausted. After taking a break from iron while using a multivitamin, I experienced hypoglycemia but felt revitalised once I resumed the iron. I believe I'll always need this supplement to maintain my energy levels.
Read More
9
Improved symptoms
7 people found this helpful
I've struggled with anaemia for 20 years and tried various supplements that upset my stomach. These iron tablets have significantly boosted my energy and clarity. Remarkably, I've finished a bottle without complications, and my symptoms have improved. I will not switch to another type of iron supplement again – this is simply fantastic.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.6
- All Researches
9.5
Vitamin B12 supplementation benefits autoimmune patients
We explored the impact of vitamin B12 on patients with autoimmune disorders, particularly those experiencing symptoms often attributed to their underlying conditions. The study presented three cases of individuals with neuropathic pain, depression, fatigue, and muscle weakness, who had their symptoms initially misattributed to rheumatic diseases.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Read More
9
Folate's Role in Rheumatoid Arthritis
We explored the potential of folate-modified ginger-derived extracellular vesicles (FA-GDEVs) in treating rheumatoid arthritis (RA). This innovative approach aims to tackle the ongoing inflammation and joint damage that characterizes this autoimmune disorder. By using folate, which selectively targets specific receptors on inflammatory cells, we specifically directed these vesicles to M1 macrophages in inflamed joints.
Our findings show that FA-GDEVs can help encourage a shift from harmful M1 macrophages to a healing M2 phenotype. This shift is significant because M2 macrophages play a role in tissue repair and reducing inflammation. We also investigated how these vesicles activate the PI3K-AKT pathway, a crucial cellular pathway involved in regulating immune response.
In our in vivo studies, we noted that these folate-modified vesicles successfully concentrated in affected joints and led to a marked reduction in RA symptoms. Overall, it’s clear that FA-GDEVs present a promising therapeutic option for those suffering from rheumatoid arthritis, bringing together safety, affordability, and effectiveness in one approach.
Our findings show that FA-GDEVs can help encourage a shift from harmful M1 macrophages to a healing M2 phenotype. This shift is significant because M2 macrophages play a role in tissue repair and reducing inflammation. We also investigated how these vesicles activate the PI3K-AKT pathway, a crucial cellular pathway involved in regulating immune response.
In our in vivo studies, we noted that these folate-modified vesicles successfully concentrated in affected joints and led to a marked reduction in RA symptoms. Overall, it’s clear that FA-GDEVs present a promising therapeutic option for those suffering from rheumatoid arthritis, bringing together safety, affordability, and effectiveness in one approach.
Read More
9
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Read More
9
We explored a unique case involving a 54-year-old man who experienced symptoms that indicated both Guillain-Barré syndrome (GBS) and complications from autoimmune gastritis (AIG). Notably, he displayed progressive numbness and weakness along with gastrointestinal symptoms, which are often linked to vitamin B12 deficiency.
As part of his treatment, we utilized intravenous immunoglobulin alongside methylcobalamin, a form of vitamin B12. What was particularly interesting is that while the immunoglobulin treatment is typically aimed at addressing GBS, vitamin B12 was also administered to combat the neurological effects stemming from the deficiency due to AIG.
Our findings revealed that following these treatments, the patient showed significant clinical improvement before discharge. However, it's crucial to note that while vitamin B12 is commonly understood to aid neurological functions, the specific impact of its isolated use in this case remains unclear without additional studies focusing solely on its effectiveness in autoimmune disorders like GBS.
Overall, the integration of vitamin B12 treatment, particularly in the context of GBS and AIG, opens up discussions about managing similar cases in the future, although further research is necessary to firmly establish its benefits.
As part of his treatment, we utilized intravenous immunoglobulin alongside methylcobalamin, a form of vitamin B12. What was particularly interesting is that while the immunoglobulin treatment is typically aimed at addressing GBS, vitamin B12 was also administered to combat the neurological effects stemming from the deficiency due to AIG.
Our findings revealed that following these treatments, the patient showed significant clinical improvement before discharge. However, it's crucial to note that while vitamin B12 is commonly understood to aid neurological functions, the specific impact of its isolated use in this case remains unclear without additional studies focusing solely on its effectiveness in autoimmune disorders like GBS.
Overall, the integration of vitamin B12 treatment, particularly in the context of GBS and AIG, opens up discussions about managing similar cases in the future, although further research is necessary to firmly establish its benefits.
Read More
9
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased ferritin levels
34 people found this helpful
I had latent iron deficiency anaemia and tried various pharmaceutical iron supplements, but my ferritin level remained low. In desperation, I ordered Iron from Garden of Life, and after three months, my ferritin rose to normal levels. This product works excellently and is gentle on the stomach. I'm feeling stronger, my hair has stopped falling out, and my general well-being has improved. I highly recommend this complex!
Read More
9
Enhanced energy
12 people found this helpful
Great iron! I bought this after positive reviews, and it really uplifted my spirits throughout the day. I've managed demanding tasks without feeling exhausted. After taking a break from iron while using a multivitamin, I experienced hypoglycemia but felt revitalised once I resumed the iron. I believe I'll always need this supplement to maintain my energy levels.
Read More
9
Improved symptoms
7 people found this helpful
I've struggled with anaemia for 20 years and tried various supplements that upset my stomach. These iron tablets have significantly boosted my energy and clarity. Remarkably, I've finished a bottle without complications, and my symptoms have improved. I will not switch to another type of iron supplement again – this is simply fantastic.
Read More
9
Increased haemoglobin
6 people found this helpful
As someone with low haemoglobin, this iron supplement was a game changer for me! After just two months, my haemoglobin levels surged by 20 units. I feel more energised and no longer experience cravings for chalk. I had a balanced diet before, but this product made all the difference. The tolerance is excellent; I’ve had no unpleasant symptoms.
Read More
9
Significant haemoglobin rise
5 people found this helpful
I've battled anaemia since childhood and have usually dealt with side effects from medications. However, this product improved my health swiftly. Within a month, my haemoglobin rose to 132. I've noticed clearer vision, enhanced energy, and better endurance. I am ordering more as I want to maintain these levels.
Read More
Frequently Asked Questions
9
Significant haemoglobin rise
5 people found this helpful
I've battled anaemia since childhood and have usually dealt with side effects from medications. However, this product improved my health swiftly. Within a month, my haemoglobin rose to 132. I've noticed clearer vision, enhanced energy, and better endurance. I am ordering more as I want to maintain these levels.
4
Mild constipation noted
The product description is misleading; the vitamin B12 content is 20833%, not 8000% as stated. Despite this, it restored my ferritin to normal in three weeks. Initially, I experienced mild constipation but resolved it by taking it with food. Although it worked, I won’t order again due to the misleading information.
9
Rapid condition improvement
3 people found this helpful
I am thrilled with the quick results! After suffering from rapid fatigue and finding low ferritin, I started taking this product. I noticed a difference by the third day, and within a week, I felt normal again. I was so happy that I ordered another can, though I don’t need it yet. I genuinely recommend this product for fast results!
9
Increased ferritin levels
34 people found this helpful
I had latent iron deficiency anaemia and tried various pharmaceutical iron supplements, but my ferritin level remained low. In desperation, I ordered Iron from Garden of Life, and after three months, my ferritin rose to normal levels. This product works excellently and is gentle on the stomach. I'm feeling stronger, my hair has stopped falling out, and my general well-being has improved. I highly recommend this complex!
9
Increased haemoglobin
6 people found this helpful
As someone with low haemoglobin, this iron supplement was a game changer for me! After just two months, my haemoglobin levels surged by 20 units. I feel more energised and no longer experience cravings for chalk. I had a balanced diet before, but this product made all the difference. The tolerance is excellent; I’ve had no unpleasant symptoms.
9
Enhanced energy
12 people found this helpful
Great iron! I bought this after positive reviews, and it really uplifted my spirits throughout the day. I've managed demanding tasks without feeling exhausted. After taking a break from iron while using a multivitamin, I experienced hypoglycemia but felt revitalised once I resumed the iron. I believe I'll always need this supplement to maintain my energy levels.
9
Reduced leg cramps
I’ve been purchasing this supplement for iron deficiency and to prevent leg cramps. I appreciate the ingredients, quality, and capsule size. I no longer experience leg cramps and I enjoy the taste as well.
0
Allergies triggered
3 people found this helpful
I have low ferritin and an autoimmune disorder, plus allergies to various foods. The product claims to be free from allergens, yet the packaging states it’s made in a facility processing allergens. I experienced diarrhoea and fatigue. Be cautious if you have allergies, as this product could pose risks despite its potential.
9
Improved energy levels
3 people found this helpful
I took this iron to replace Hemaplex, as I had low haemoglobin which led to weakness and pale skin after suffering from COVID-19. After a month on this supplement, I feel significantly better — my haemoglobin has normalised, I have more energy, and there’s colour back in my cheeks. This iron includes co-factors like B12 and vitamin C for better absorption. The brand is excellent, and I trust it, so I will order more.
8
We investigated the potential of vitamin B12 as a treatment for rheumatoid arthritis, particularly focusing on its ability to target an enzyme called peptidylarginine deiminase isoform 4 (PADI-4). PADI-4 plays a crucial role in a process called citrullination, which is often disrupted in autoimmune conditions like rheumatoid arthritis.
Our findings revealed that vitamin B12 effectively inhibits PADI-4, showing a preference for this enzyme over another similar one, PADI-2. This inhibition corresponds to a decrease in overall cellular citrullination, including the citrullination of histone H3, which is also mediated by PADI-4.
Additionally, we observed that hydroxocobalamin, a special form of vitamin B12, significantly reduced the severity of collagen type II antibody-induced arthritis in mice. It also lowered the expression of key inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL-17A, TNFα, and IL-6.
These promising results suggest that vitamin B12 might be an effective therapeutic avenue for managing rheumatoid arthritis, warranting further investigation in future studies.
Our findings revealed that vitamin B12 effectively inhibits PADI-4, showing a preference for this enzyme over another similar one, PADI-2. This inhibition corresponds to a decrease in overall cellular citrullination, including the citrullination of histone H3, which is also mediated by PADI-4.
Additionally, we observed that hydroxocobalamin, a special form of vitamin B12, significantly reduced the severity of collagen type II antibody-induced arthritis in mice. It also lowered the expression of key inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL-17A, TNFα, and IL-6.
These promising results suggest that vitamin B12 might be an effective therapeutic avenue for managing rheumatoid arthritis, warranting further investigation in future studies.
9.5
Vitamin B12 supplementation benefits autoimmune patients
We explored the impact of vitamin B12 on patients with autoimmune disorders, particularly those experiencing symptoms often attributed to their underlying conditions. The study presented three cases of individuals with neuropathic pain, depression, fatigue, and muscle weakness, who had their symptoms initially misattributed to rheumatic diseases.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
8
Folic acid aids RA treatment safety
We investigated the role of folic acid supplementation in helping elderly patients with rheumatoid arthritis (RA) who are treated with methotrexate (MTX). This study focused on understanding the incidence of adverse events (AEs) that lead patients to stop using MTX over time. We reviewed clinical data from 198 elderly RA patients who were receiving MTX in an outpatient rheumatology setting.
Over a period of 15 years, we found that the likelihood of patients stopping MTX due to AEs increased significantly, with rates reaching as high as 51.7%. Notably, we observed that higher doses of MTX (15 mg/wk or more) substantially raised the risk of withdrawal. In contrast, patients who took folic acid alongside their MTX therapy were less likely to discontinue treatment, suggesting a protective effect of folic acid against some of the adverse reactions.
Overall, our findings indicate that while MTX is a common treatment for RA, utilizing lower doses along with folic acid supplementation can help manage the risks associated with this medication. This approach could lead to improved long-term treatment outcomes for elderly patients with RA, allowing them to better navigate the challenges of their condition.
Over a period of 15 years, we found that the likelihood of patients stopping MTX due to AEs increased significantly, with rates reaching as high as 51.7%. Notably, we observed that higher doses of MTX (15 mg/wk or more) substantially raised the risk of withdrawal. In contrast, patients who took folic acid alongside their MTX therapy were less likely to discontinue treatment, suggesting a protective effect of folic acid against some of the adverse reactions.
Overall, our findings indicate that while MTX is a common treatment for RA, utilizing lower doses along with folic acid supplementation can help manage the risks associated with this medication. This approach could lead to improved long-term treatment outcomes for elderly patients with RA, allowing them to better navigate the challenges of their condition.
We looked into how folate, an essential nutrient in our diet, might influence the health of individuals with systemic lupus erythematosus (SLE), an autoimmune disorder that carries a heightened risk of cardiovascular disease. Our investigation involved a case-control study with 394 Mexican-mestizo women, where we sought to find connections between certain genetic variants related to folate metabolism and heart health in SLE patients.
Surprisingly, our results showed that the overall levels of folate and homocysteine—both important in the context of heart health—didn't differ significantly between those with SLE and healthy controls. However, we did observe that the genetic variant c.+677 C>T (known as the CC genotype) appeared to offer some protective benefit against cardiovascular issues, suggesting that people with this genetic makeup might have a lower risk of heart disease.
On the flip side, two specific haplotypes from the c.+677 and c.+1298 genetic variants were linked to an increased risk for SLE itself. This suggests that while folate's role in the body is vital and its genetic connections intricate, treating SLE patients with folate alone may not yield significant improvements in their condition based on these findings.
Overall, while we documented interesting associations between genetic variants and disease risk in SLE, we didn't find strong evidence supporting direct benefits of folate treatment in mitigating the disorder's impact.
Surprisingly, our results showed that the overall levels of folate and homocysteine—both important in the context of heart health—didn't differ significantly between those with SLE and healthy controls. However, we did observe that the genetic variant c.+677 C>T (known as the CC genotype) appeared to offer some protective benefit against cardiovascular issues, suggesting that people with this genetic makeup might have a lower risk of heart disease.
On the flip side, two specific haplotypes from the c.+677 and c.+1298 genetic variants were linked to an increased risk for SLE itself. This suggests that while folate's role in the body is vital and its genetic connections intricate, treating SLE patients with folate alone may not yield significant improvements in their condition based on these findings.
Overall, while we documented interesting associations between genetic variants and disease risk in SLE, we didn't find strong evidence supporting direct benefits of folate treatment in mitigating the disorder's impact.
References
- Shao W, Liu F, Zhu L, Qian W, Meng Q, et al. Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway. Eur J Pharmacol. 2025;987:177205. doi:10.1016/j.ejphar.2024.177205
- Sun L, Niu Y, Liao B, Liu L, Peng Y, et al. CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis. Inflamm Res. 2025;74:53. doi:10.1007/s00011-025-02019-2
- Shin HG, Kim W, Lee JH, Lee HS, Nam Y, et al. Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI. Neuroimage Clin. 2025;45:103748. doi:10.1016/j.nicl.2025.103748
- Han R, Zhou D, Ji N, Yin Z, Wang J, et al. Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway. J Nanobiotechnology. 2025;23:41. doi:10.1186/s12951-025-03096-5
- Nasra S, Bhatia D, Kumar A. Targeted Macrophage Re-Programming: Synergistic Therapy With Methotrexate and RELA siRNA Folate-Liposome in RAW264.7 Cells and Arthritic Rats. Adv Healthc Mater. 2024;13:e2400679. doi:10.1002/adhm.202400679
- Pesqueda-Cendejas K, Parra-Rojas I, Campos-López B, Mora-García PE, Ruiz-Ballesteros AI, et al. Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study. Lupus. 2024;33:918. doi:10.1177/09612033241257158
- Avalos-Salgado FA, Gonzalez-Lopez L, Gonzalez-Vazquez S, Ponce-Guarneros JM, Santiago-Garcia AP, et al. Risk Factors Associated with Adverse Events Leading to Methotrexate Withdrawal in Elderly Rheumatoid Arthritis Patients: A Retrospective Cohort Study. J Clin Med. 2024;13. doi:10.3390/jcm13071863
- Patel AV, Morgan SL, Green R, Danila MI, Merriman TR, et al. Vitamin B12 status and hyperhomocysteinemia in patients with Rheumatoid arthritis treated with methotrexate and folic acid. Am J Med Sci. 2024;368:33. doi:10.1016/j.amjms.2024.03.020
- Wells L, O'Hara N, Frye RE, Hullavard N, Smith E. Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population. J Pers Med. 2024;14. doi:10.3390/jpm14020166
- Ma XY, Hao Y, Xie YH, Cao Q, Sun DF, et al. Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China. J Gastroenterol Hepatol. 2025. doi:10.1111/jgh.16912
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Subtil J, Carvalho R, Rebelo AF, Subtil P. Autoimmune Polyglandular Syndrome Type 3: A Case Report. Cureus. 2024;16:e76152. doi:10.7759/cureus.76152
- Mansour M, Shamasnah A, Alsaadi D, Abu Saif S, Krama A. Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto's thyroiditis and pernicious anemia: a case report. J Med Case Rep. 2024;18:643. doi:10.1186/s13256-024-05002-3
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
- Xiang H, Cai M. Coexistence of Guillain-Barré Syndrome and Subacute Combined Degeneration of the Spinal Cord Due to Autoimmune Gastritis: A Case Report and Literature Review. Cureus. 2024;16:e63084. doi:10.7759/cureus.63084
- Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, et al. Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Sci Transl Med. 2024;16:eadl3758. doi:10.1126/scitranslmed.adl3758
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. doi:10.7759/cureus.58601
- Fernandez I, Touzot F. Looking for ALPS: The value of a combined assessment of biochemical markers. Pediatr Allergy Immunol. 2024;35:e14135. doi:10.1111/pai.14135
- Yamada H, Toko M, Nakamori M, Ueno H, Aoki S, et al. Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging. J Neurovirol. 2024;30:197. doi:10.1007/s13365-024-01203-0
- Yang CW, Hsu HY, Lee YZ, Lee SJ. Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice. Biochem Biophys Res Commun. 2024;704:149668. doi:10.1016/j.bbrc.2024.149668
- Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. doi:10.1007/s00296-024-05539-y
